"There are currently quite a few different ways of developing a web application in python. When you add in how you deploy the application as well, there are even more choices. In terms of application frameworks, you have at least:
Then these can be run using many different servers, including: And many more. Typically, these take one of several approaches. Asynchronous either explicit (cyclone, tornado) or via monkey patch and event loop (gevent); threaded such as rocket, or written in C to use an event loop. In addition to this, you now have several different pythons for deployment: At some point, these servers are generally dealing with asynchronous event loops or using threading. The two approaches to handling this are either to program in a normal style (gevent) or to explicitly use event based programming (eg cyclone). The rise of javascript and node.js has seen event based programming becoming more mainstream. I wanted to find out which of these many combinations would perform best, and in particular what effect using pypy as the interpreter would have on the performance..." http://casbon.me/what-will-pypy-do-for-your-website-benchmarki